Aparna Jayachandran
Scientist
Jonathan Cebon Lab Ludwig Center at Melbourne
Ludwig Institute for Cancer Research
Australia
Biography
Melanoma is potentially fatal and one of the most common forms of skin cancer. Major challenges in the treatment of melanoma are its high motile abilities and its capacity to change cellular states (inherent plasticity or termed epithelial to mesenchymal transition, allowing for treatment escape). These dynamic events are poorly understood and the subject of intense research worldwide. I am investigating whether melanoma cells can hijack the developmental EMT process to enhance their motility. I am particularly interested in identifying and targeting molecular pathways and genes that these cancer cells rely on for spreading to distant organs.
Research Interest
Melanoma cell biology and immunology
Publications
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Jayachandran, Aparna, et al. "Thrombospondin 1 promotes an aggressive phenotype through epithelial-to-mesenchymal transition in human melanoma." Oncotarget 5.14 (2014): 5782.
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Lange-Sperandio, Bärbel, et al. "Leukocytes induce epithelial to mesenchymal transition after unilateral ureteral obstruction in neonatal mice." The American journal of pathology 171.3 (2007): 861-871.
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Yu, Haiying, et al. "Transgelin is a direct target of TGF-β/Smad3-dependent epithelial cell migration in lung fibrosis." The FASEB Journal 22.6 (2008): 1778-1789.
