Elgene Lim
Scientist
Jonathan Cebon Lab Ludwig Center at Melbourne
Ludwig Institute for Cancer Research
Australia
Biography
I completed my medical training at the University of Melbourne, Australia after which I spent three years in the military, returning to finish my Internal Medicine residency at the Royal Melbourne Hospital and a fellowship in Medical Oncology with the Royal Australasian College of Physicians. I earned my PhD in Molecular Biology at the Walter & Eliza Hall Institute of Medical Research under the mentorship of Geoffrey Lindeman and Jane Visvader focused on the mammary epithelial cell hierarchy, aberrant changes in the mammary glands of BRCA1 germline mutation carriers, and the development of patient-derived breast cancer xenografts in mice for the developing of novel therapies.I returned to Melbourne in 2014 as a Senior Clinical Research Fellow at the Ludwig Institute and Staff Oncologist at Austin Health, with research funding obtained from the National Breast Cancer Foundation and Victorian Cancer Agency. The Translational Breast Cancer Laboratory’s focus is to identify key differences in steroid receptor signaling between normal and breast cancer tissue, and the preclinical evaluation of novel therapeutics and biomarkers in vitro and in vivo using patient-derived breast cancer xenograft models.
Research Interest
Mutation carriers, cancer biology, breast cancer, cancer therapy
Publications
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Oakes, Samantha R., et al. "Sensitization of BCL-2–expressing breast tumors to chemotherapy by the BH3 mimetic ABT-737." Proceedings of the National Academy of Sciences 109.8 (2012): 2766-2771.
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Ni, Min, et al. "Targeting androgen receptor in estrogen receptor-negative breast cancer." Cancer cell 20.1 (2011): 119-131.
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Lim, Elgene, et al. "Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers." Nature medicine 15.8 (2009): 907-913.