Hoanh Tran
Scientist
John M. Mariadason Lab Ludwig Center at Melbourne
Ludwig Institute for Cancer Research
Australia
Biography
I am a molecular cell biologist motivated by a mechanistic understanding of cancer cell biology. My research focus is the Wnt signaling pathway. Aberrant activation of Wnt signaling is a hallmark of the majority of human colorectal cancers. My goal is to identify transcriptional events downstream of Wnt pathway activation unique to colon cancer cells. A thorough molecular understanding of Wnt-mediated transcription could reveal novel therapeutic strategies for colorectal cancer.
Research Interest
Cancer cell biology, cell signaling pathways, colorectal cancers, therapeutics
Publications
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Ekman, Maria, et al. "APC and Smad7 link TGFβ type I receptors to the microtubule system to promote cell migration." Molecular biology of the cell 23.11 (2012): 2109-2121.
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Diesch, Jeannine, et al. "Widespread FRA1-dependent control of mesenchymal transdifferentiation programs in colorectal cancer cells." PloS one 9.3 (2014): e88950.
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Tran, Hoanh, et al. "Trabid, a new positive regulator of Wnt-induced transcription with preference for binding and cleaving K63-linked ubiquitin chains." Genes & development 22.4 (2008): 528-542.