John M. Mariadason
Director, John M. Mariadason Lab
John M. Mariadason Lab Ludwig Center at Melbourne
Ludwig Institute for Cancer Research
Australia
Biography
I received my PhD in 1998 from the University of Melbourne. I then undertook postdoctoral training at Montefiore Medical Center/Albert Einstein College of Medicine in the Bronx, New York, USA, investigating the role of Wnt signaling in colon cancer progression and the use of gene expression profiling for predicting response of colon cancer cells to chemotherapy. In 2001 I established my independent laboratory at Albert Einstein as Assistant Professor of Medicine, and in 2008 was appointed Associate Professor of Medicine. In 2008 I joined the Ludwig Institute in Melbourne as Head of the Oncogenic Transcription Laboratory. I am currently Professor and Head of the Oncogenic Transcription Laboratory at the Olivia Newton-John Cancer Research Institute. Our laboratory is supported through grants from the NHMRC, Victorian Cancer Agency and Ludwig Cancer Research.
Research Interest
Colon cancer, gene expression, chemotherapy
Publications
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Mariadason, John M., Georgia A. Corner, and Leonard H. Augenlicht. "Genetic reprogramming in pathways of colonic cell maturation induced by short chain fatty acids: comparison with trichostatin A, sulindac, and curcumin and implications for chemoprevention of colon cancer." Cancer research 60.16 (2000): 4561-4572.
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Jhawer, Minaxi, et al. "PIK3CA mutation/PTEN expression status predicts response of colon cancer cells to the epidermal growth factor receptor inhibitor cetuximab." Cancer research 68.6 (2008): 1953-1961.
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Wilson, Andrew J., et al. "Histone deacetylase 3 (HDAC3) and other class I HDACs regulate colon cell maturation and p21 expression and are deregulated in human colon cancer." Journal of Biological Chemistry 281.19 (2006): 13548-13558.
