Michael Buchert
Scientist
Matthias Ernst Lab Ludwig Center at Melbourne
Ludwig Institute for Cancer Research
Australia
Biography
My research focuses on gastrointestinal tumors with a view to uncover the molecular mechanisms that drive and modulate cancer initiation and progression. I use state-of-the-art Cre/LoxP mouse models of colon and stomach cancer to study the contribution of various signaling pathways to tumorigenesis. These studies will help to identify novel signaling components that are critically important for tumor maintenance, growth and survival and should lead to the development of novel treatment options for use in clinical trials.
Research Interest
Tumor biology, therapeutics, clinical trials
Publications
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Halford, Michael M., et al. "Ryk-deficient mice exhibit craniofacial defects associated with perturbed Eph receptor crosstalk." Nature genetics 25.4 (2000): 414.
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Ernst, Matthias, et al. "STAT3 and STAT1 mediate IL-11–dependent and inflammation-associated gastric tumorigenesis in gp130 receptor mutant mice." The Journal of clinical investigation 118.5 (2008): 1727.
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Schorle, Hubert, et al. "Transcription factor AP-2 essential for cranial closure and craniofacial development." Nature 381.6579 (1996): 235.
