Robert O’donoghue
Scientist
Matthias Ernst Lab Ludwig Center at Melbourne
Ludwig Institute for Cancer Research
Australia
Biography
My research investigates the molecular mechanisms underlying tissue responses inflammation, regeneration and cancer, with an emphasis on the IL-6 family of cytokines. The focus of my research is to understand how cells of the innate immune system, particularly macrophages, mediate the phenotype and behavior of epithelial cells in inflammatory diseases, fibrosis and cancer in the pulmonary and gastrointestinal systems.
Research Interest
Pulmonary and gastrointestinal cancers
Publications
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O'donoghue, Robert JJ, et al. "Genetic partitioning of interleukinâ€6 signalling in mice dissociates Stat3 from Smad3â€mediated lung fibrosis." EMBO molecular medicine 4.9 (2012): 939-951.
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Haegens, Astrid, et al. "Myeloperoxidase deficiency attenuates lipopolysaccharide-induced acute lung inflammation and subsequent cytokine and chemokine production." The Journal of Immunology 182.12 (2009): 7990-7996.
