Toby Phesse
Scientist
Matthias Ernst Lab Ludwig Center at Melbourne
Ludwig Institute for Cancer Research
Australia
Biography
My primary research focus is the use of mouse models to study the role of deregulated cell signaling during cancer and other diseases. In 2004 I secured a post-doctoral position with Alan Clarke at Cardiff University, UK. We published several papers describing the role of Wnt signaling during homeostasis and tumorigenesis in organs, including liver, prostate and intestine. In 2008 I moved to Melbourne to continue this research with Matthias Ernst, publishing a paper describing the role of Stat3 during colitis associated cancer. I have obtained two NHMRC project grants as CIA using mouse models to study signaling in disease.
Research Interest
Cell signaling, tumorigenesis
Publications
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Rickard, James A., et al. "RIPK1 regulates RIPK3-MLKL-driven systemic inflammation and emergency hematopoiesis." Cell 157.5 (2014): 1175-1188.
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Sansom, Owen J., et al. "Myc deletion rescues Apc deficiency in the small intestine." Nature 446.7136 (2007): 676.
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Bollrath, Julia, et al. "gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis." Cancer cell 15.2 (2009): 91-102.
