Helen Rizos
ProfessorÂ
Department & Professor Cancer Cell Biology
Macquarie University
Australia
Biography
Professor Rizos is a cancer cell biologist with an international reputation in the field of melanoma senescence, tumour suppressor proteins and oncoproteins. Her work combines genetic analyses of melanoma tumours with functional molecular and cell biology in order to understand the role and regulation of genes and cellular pathways that influence the development and therapeutic response of melanoma. This work will define the targetable mechanisms of sensitivity and response to selective oncogene inhibitors and immunotherapies in melanoma.
Research Interest
Melanoma senescence, Tumour suppressor proteins and Oncoproteins genes and Cellular pathways
Publications
-
Gray, E. S., Rizos, H., Reid, A. L., Boyd, S. C., Pereira, M. R., Lo, J., Tembe, V., Freeman, J., Lee, J. H., Scolyer, R. A., Siew, K., Lomma, C., Cooper, A., Khattak, M. A., Meniawy, T. M., Long, G. V., Carlino, M. S., Millward, M., and Ziman, M. (2015) Circulating tumour DNA to monitor treatment response and detect acquired resistance in patients with metastatic melanoma. Oncotarget (in press)
-
Long, G. V., Fung, C., Menzies, A. M., Pupo, G. M., Carlino, M. S., Hyman, J., Shahheydari, H., Tembe, V., Thompson, J. F., Saw, R. P., Howle, J., Hayward, N. K., Johansson, P., Scolyer, R. A., Kefford, R. F., and Rizos, H. (2014) Increased MAPK reactivation in early resistance to dabrafenib/trametinib combination therapy of BRAF-mutant metastatic melanoma. Nat Commun5, 5694
-
Carlino, M. S., Todd, J. R., Gowrishankar, K., Mijatov, B., Pupo, G. M., Fung, C., Snoyman, S., Hersey, P., Long, G. V., Kefford, R. F., and Rizos, H. (2014) Differential activity of MEK and ERK inhibitors in BRAF inhibitor resistant melanoma. Mol Oncol 8, 544-554
