Helena Nevalainen
Department of Chemistry and Biomolecular Sciences
Macquarie University
Australia
Biography
Professor at Macquarie University
Research Interest
Research interests are focused on (molecular) biology and enzymology of biotechnologically important filamentous fungi, in particular Trichoderma reesei. T. reesei offers a powerful system for efficient expression of foreign gene products originating from other micro-organisms, plants and animals. Other research interests include biological roles of cell walls in fungi and molecular prospecting of the environment for novel bioactivities. The research topics are: Development of vectors and hosts for efficient expression and secretion of gene products from T. reesei. Expression of thermophile enzyme genes in Trichoderma. Proteomes of Trichoderma. Mapping of cell wall-associated proteins in Trichoderma by 2-D electrophoresis. Emphasis is on the identification of proteins related to secretion and heterologous gene expression. Molecular prospecting of the environment. Screening of novel enzyme activities and their genes from Antarctic fungi and unculturable microorganisms.
Publications
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Nevalainen KH, Te'o VS, Bergquist PL. Heterologous protein expression in filamentous fungi. Trends in biotechnology. 2005 Sep 30;23(9):468-74.
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Penttilä M, Lehtovaara P, Nevalainen H, Bhikhabhai R, Knowles J. Homology between cellulase genes of Trichoderma reesei: complete nucleotide sequence of the endoglucanase I gene. Gene. 1986 Dec 31;45(3):253-63.
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Penttilä M, Nevalainen H, Rättö M, Salminen E, Knowles J. A versatile transformation system for the cellulolytic filamentous fungus Trichoderma reesei. Gene. 1987 Dec 31;61(2):155-64.
