Amanda Fosang
Professor
Cell Biology
Murdoch Childrens Research Institute
Australia
Biography
Professor Amanda Fosang has an established career researching cartilage biology in health and disease. After completing her postdoctoral studies at the Kennedy Institute of Rheumatology in London, she returned to Australia and was awarded an RD Wright Fellowship by the NHMRC in 1994. Since then she has received continuous competitive grant and fellowship funding from the NHMRC. She joined the University of Melbourne, Department of Paediatrics in 1994 and became a group leader of Murdoch Childrens Research Institute at its inception in 2000. Professor Fosang has generated unique genetically-modified mice for evaluating cartilage damage in arthritic disease. Her work showing that the ADAMTS-5 protein is the major proteinase in mouse cartilage was published in Nature in 2005. She joined the Board of Directors for the Osteoarthritis Research Society International (OARSI) in 2012 and is the first Australian appointed as an Associate Editor to the Journal of Biological Chemistry. She has supervised numerous students to course completion.
Research Interest
Arthritis, Cell Biology and Rheumatology
Publications
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Fosang AJ, Golub SB, East CJ, Rogerson FM. Abundant LacZ activity in the absence of Cre expression in the normal and inflamed synovium of adult Col2a1-Cre; ROSA26RLacZ reporter mice. Osteoarthritis and cartilage. 2013 Feb 1;21(2):401-4.
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Fosang AJ, Colbran RJ. Transparency Is the Key to Quality. Journal of Biological Chemistry. 2015 Dec 11;290(50):29692-4.
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Kosasih HJ, Last K, Rogerson FM, Golub SB, Gauci SJ, Russo VC, Stanton H, Wilson R, Lamande SR, Holden P, Fosang AJ. A disintegrin and metalloproteinase with thrombospondin motifs-5 (ADAMTS-5) forms catalytically active oligomers. Journal of Biological Chemistry. 2016 Feb 12;291(7):3197-208.
