Andrew Sinclair
Professor
Cell Biology
Murdoch Childrens Research Institute
Australia
Biography
Professor Andrew Sinclair is Deputy Director of the Murdoch Childrens Research Institute at the Royal Children's Hospital in Melbourne. He is also a Professorial Fellow in the Department of Pediatrics at the University of Melbourne. Professor Sinclair leads an NHMRC Program focusing on the molecular genetics of gonad development and its impact on patients with disorders of sex development (DSD) and is part of a team awarded a National Centre of Excellence focusing on the regulation of male germ cell differentiation and its impact on infertility and testicular cancer. His contributions have been fundamental to the advancement of the field, including the identification and characterization of the human testis determining gene (SRY) and other genes critical for gonad development. He has also implemented new, accurate, rapid and comprehensive diagnostic procedures to improve outcomes for patients with DSD. Professor Sinclair has an extensive publication record, including seven Nature papers, with one listed as an ISI citation classic. Altogether his publications have been cited over 6,800 times. While President of the Australian Society for Medical Research in 2004 he led national advocacy efforts seeking increased Federal Government funding for health and medical research. He is an editorial board member of several international journals.
Research Interest
Cell Biology,Pediatrics and Molecular Biology
Publications
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Western PS, van den Bergen JA, Miles DC, Sinclair AH. Male fetal germ cell differentiation involves complex repression of the regulatory network controlling pluripotency. The FASEB Journal. 2010 Aug 1;24(8):3026-35.
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Smith CA, Roeszler KN, Ohnesorg T, Cummins DM, Farlie PG, Doran TJ, Sinclair AH. The avian Z-linked gene DMRT1 is required for male sex determination in the chicken. Nature. 2009 Sep 10;461(7261):267-71.
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Western PS, Miles DC, Van Den Bergen JA, Burton M, Sinclair AH. Dynamic regulation of mitotic arrest in fetal male germ cells. Stem cells. 2008 Feb 1;26(2):339-47.
