Adam Mccluskey
School of Environmental and Life Sciences
Newcastle University
Australia
Biography
"I am a (BScHons and PhD) graduate in chemistry of the University of Strathclyde, Scotland.My primary area of resaerch is in the medicinal chemistry / chemical biology space where my main focus is in the development of tool compounds, and drugs, targeting endocytosis. The potential outcomes of our research include (but are not limited to) the development of new synthetic methodologies; the development of new drugs & the development of new tools for dissecting signal transduction pathways. This led to the establishment of the dynamin modulators platform of which I am team leader (chemistry). This team interacts with, and supplies the only known endocytosis inhibitors to research teams worldwide (UK, USA, Germany, Denmark etc). I am also an integral component of the development of new anti-epileptic drugs alongside the National Institute of Health, National Institute of Neurological Disorders and Stroke (Bethesda USA). I head the chemistry component of the Australian Cancer Research Foundation (supported by Ramaciotti) Centre for Kinomics (CFK), a new approach for direct profiling of cellular kinases, a multi-million dollar initiative providing a unique service to multiple research teams throughout Australia. Kinases are the cancer drug target of the 21st century. The CFK offers a unique opportunity to profile biological probes (drugs) and cellular kinases to identify new therapeutic targets, new uses for old drugs and rapid IC50 determination of individual compounds against the entire cellular kinome (cellular complement of protein kinases). The CFK at the University of Newcastle has established one of the first fully equipped flow chemistry laboratories in Australia."
Research Interest
Biologically Active Molecules, Organic Chemical Synthesis
Publications
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Schwarz L, Holdsworth CI, McCluskey A, Bowyer MC. Synthesis and evaluation of a molecularly imprinted polymer selective to 2, 4, 6-trichlorophenol. Australian journal of chemistry. 2004 Aug 30;57(8):759-64.
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Wright AD, McCluskey A, Robertson MJ, MacGregor KA, Gordon CP, Guenther J. Anti-malarial, anti-algal, anti-tubercular, anti-bacterial, anti-photosynthetic, and anti-fouling activity of diterpene and diterpene isonitriles from the tropical marine sponge Cymbastela hooperi. Organic & biomolecular chemistry. 2011;9(2):400-7.
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McCluskey A, Holdsworth CI, Bowyer MC. Molecularly imprinted polymers (MIPs): sensing, an explosive new opportunity?. Organic & biomolecular chemistry. 2007;5(20):3233-44.
