Andrew Cox
Team leader in the Organogenesis and Cancer Progam
Medicine
Peter MacCallum Cancer Centre
Australia
Biography
Dr Andrew Cox earned his BSc and MSc degrees from the University of Canterbury, New Zealand. In 2009, Dr Cox received his PhD from the University of Otago, New Zealand. He then undertook postdoctoral training with Prof. Wolfram Goessling at Brigham and Women’s Hospital, Harvard Medical School. Dr Cox was promoted to Instructor in Medicine at Harvard Medical School in 2013. In 2016, Dr Cox became a team leader in the Organogenesis and Cancer Progam at the Peter MacCallum Cancer Centre and holds a joint appointment in the Department of Biochemistry and Molecular Biology at the University of Melbourne. His laboratory uses zebrafish as a model system to elucidate pathways involved in liver regeneration and cancer. A central theme of his work is to understand how the Hippo pathway reprograms metabolism to fuel cancer cell growth.
Research Interest
LIVER CANCER, METABOLISM, ZEBRAFISH MODELS OF CANCER
Publications
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Mitochondrial dysfunction remodels one-carbon metabolism in human cells. Bao XR, Ong SE, Goldberger O, Peng J, Sharma R, Thompson DA, Vafai SB, Cox AG, Marutani E, Ichinose F, Goessling W, Regev A, Carr SA, Clish CB, Mootha VK. eLife. 2016; 5.
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Selenoprotein H is an essential regulator of redox homeostasis that cooperates with p53 in development and tumorigenesis. Cox AG, Tsomides A, Kim AJ, Saunders D, Hwang KL, Evason KJ, Heidel J, Brown KK, Yuan M, Lien EC, Lee BC, Nissim S, Dickinson B, Chhangawala S, Chang CJ, Asara JM, Houvras Y, Gladyshev VN, Goessling W. Proceedings of the National Academy of Sciences of the United States of America. 2016; 113(38):E5562-71.
