Kaylene Simpson
Associate Professor
Medicine
Peter MacCallum Cancer Centre
Australia
Biography
Associate Professor Kaylene Simpson Heads the Victorian Centre for Functional Genomics (VCFG) at Peter MacCallum Cancer Centre. The VCFG enables researchers Australia-wide to perform unbiased gene discovery using high throughput gene targeting approaches such as CRISPR/cas9 and RNA interference, quantitative Reverse Phase Protein Arrays, boutique compound screening and high content imaging. She leads a highly experienced team who actively engage with researchers to help drive their research projects to fruition. Associate Professor Simpson is a molecular cell biologist who specialised in breast cancer invasion and metastasis while a postdoctoral fellow at Harvard Medical School. She has a wealth of experience in assay development, data interpretation and analysis and overall guidance in the area of functional genomics. She contributes intellectually to all projects and technology initiatives within the platform and collaborates with several Peter Mac Group Leaders to supervise PhD students.
Research Interest
GENE DISCOVERY HIGH THROUGHPUT SCREENING – CRISPR/CAS9, RNAI, RPPA, HIGH CONTENT IMAGING
Publications
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Telford B, Chen A, Beethan H, Frick J, Brew T, Gould CM, Single A, Godwin T, Simpson KJ and Guilford P. Synthetic lethal screens identify vulnerabilities in GPCR signalling and cytoskeletal organisation in E-cadherin-deficient cells. Molecular Cancer Therapeutics, 2015; 14(5):1213-23.
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Bhaskar Dutta,Alaleh Azhir, Louis-Henri Merino, Yongjian Guo, Swetha Revanur, Piyush Madhamshettiwar, Ronald N. Germain, Jennifer A. Smith, Kaylene J. Simpson, Scott E. Martin, Eugen Beuhler and Iain D.C. Fraser. CARD: an interactive web-based application for Comprehensive Analysis of RNAi-screen Data. Nature Communications 2016 Feb23;7:10578.
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Falkenberg KJ, Gould CM, Luu J, Matthews GM, Simpson KJ and Johnstone RW. A genome scale siRNA screen reveals GLI1 as a novel gene regulating vorinostat sensitivity. Cell Death and Differentiation 2016 Feb12. doi: 10.1038/cdd.2015.175.
