Stuart Kellie

Biography

I was an MRC Postdoctoral Research Fellow at University of Leicester, UK 1980-3, and a postdoctoral fellow at the Imperial Cancer Research Fund laboratories, London 1983-6. After a 6 month EMBO Fellowship to the Ludwig Institute for Cancer Research in Berne, Switzerland, in 1986 I was appointed Lecturer in Biochemistry at the Royal College Surgeons (Univ. London). In 1990 I was appointed Group Leader at Yamanouchi Research Institute, Oxford. In 2002 I joined The University of Queensland as Senior Lecturer, and promoted to Associate Professor in 2006. From 2000-8 I was Deputy CEO of the CRC for Chronic Inflammatory Diseases (CRC-CID). I have international collaborations with Profs Chris Buckley and Steve Watson (University of Birmingham, UK); Prof Simon Lovestone and Dr. Richard Killick (Kings College London).

Research Interest

My interests lie in the cell and molecular biology of phagocyte function. Phagocytes such as macrophages play a central role in both the innate and acquired immune response. Furthermore aberrant activation of these cells can lead to chronic inflammatory diseases. My interests are in identifying and functionally characterising novel macrophage genes that are associated with inflammation, and in intracellular signalling pathways in macrophages. I am particularly interested in the family of molecules known as tyrosine phosphatases and their role in regulating macrophage function. Current research projects include the molecular mechanisms underlying the regulation of monocyte function by the phosphatase CD148; the role of furin-like molecules in Respiratory Syncytial Virus infection (with Prof Paul Young); the functional characterisation of macrophage genes upregulated by acute and chronic inflammatory stimuli (with Dr. Matt Sweet); cell and structural biology of macrophage signaling proteins (with Profs Bostjan Kobe and Jenny Martin and Dr. Matt Sweet); the use of yeast expression as a biological screen for signalling molecule inhibitors. Secondary Research Areas: Molecular Genetics and Genomics Science Education Structural Biology and Biochemistry