Eugene Roscioli

Biography

Dr Eugene Roscioli is an Early Career Research Fellow for the Royal Adelaide Hospital's Department of Thoracic Medicine, and Lecturer (Level B) for the University of Adelaide. His current focus within the Chronic Inflammatory Lung Research Laboratory is determining the influence of dysregulated autophagy (cellular recycling) and dyshomeostasis of Zinc trafficking in the airways afflicted by Chronic Obstructive Pulmonary Disease. He examines the contribution of the airway epithelium and macrophages in the context of respiratory disease, and has developed specialist skills in the generation of disease-models of the human airway (see insert). Success with this research trajectory is evidenced by the Thoracic Society of Australia and New Zealand (TSANZ) / AstraZeneca Pty Ltd Respiratory ECR Fellowship Award, Cat 1 HNMRC clinical project grant funding for the project entitled "Targeting autophagy in bronchial epithelial cells: a new therapeutic approach for chronic obstructive pulmonary disease", and his output from this CPG has recently recognised (March 2017) with the Japanese Career Development Award (TSANZ). With his research team, Dr Roscioli has shown that epithelial and macrophage-targeted therapies including macrolide antibiotics have properties that restore airway function in this context, in addition to combatting microbial infection by Nontypeable haemophilus influenza (NTHi) which is responsible for approximately 50% of all COPD exacerbations. He is currently investigating the efficacy of these and related therapeutics in combination with agents that restore autophagy and Zinc regulation, to contribute in the efforts to holding back the growing and devastating global effects of COPD.

Research Interest

Medicine,Medical Education,Research,etc