Karagh Loring

Biography

Intellectual disability (ID) affects 1 in 50 people worldwide, with genetic causes responsible for ~40% of these case. Up to 30% of children with ID also present with seizures, most unresponsive to anti-convulsant therapy, thus the need for treatment is high. Using mouse models with mutations in a known ID and seizure gene, ARX, we will investigate the effectiveness of short-term estradiol treatment on symptom alleviation. As part of this analysis I will monitor improvements to the onset and frequency of seizures, in conjunction with improvements in behavioural and cognitive deficits. My analysis will begin to elucidate the molecular and cellular changes following treatment that lead to phenotypic improvements. This knowledge may lead to future targets for therapeutic interventions for these patients

Research Interest

Medicine,Medical Education,Research,etc