University of Canberra
Fan's research focuses on investigating epigenetic and immunology mechanism on cancer stem cells on in vitro cell lines and in vivo clinical samples from different types of human cancers. Recently, we have established a rapid inducible model of cancer stem cells to study the mechanism of cancer stem cells formation. We have shown that nuclear factor kappa B (NF-κB) associate with chromatinized PKC-θ to play an irreplaceable role in modulating breast cancer stem cells formation both in vitro and in vivo. Our current interest is to develop peptide inhibitor/vaccine to target on the key proteins, which regulate cancer stem cells to abolish cancer metastasis and cancer reoccurrence, and to increase the survival rate of patients post chemo-therapy in breast, pancreatic and ovarian cancers.
Biomedical discovery for disease prevention and treatment.