Arthur Conigrave
Dean
Molecular Bioscience
University of Sydney
Australia
Biography
Professor Arthur Conigrave was appointed Dean of Sydney Medical School in 2016. As Dean, he leads one of the largest medical schools in Australia and the most research-intensive faculty within the University of Sydney. Sydney Medical School has more than 3000 academic faculty members and teaches over 5000 students across undergraduate medical sciences, medicine, postgraduate professional courses and higher research degrees. Prior to his appointment as Dean, Professor Conigrave held a number of leadership roles including Head of the School of Molecular Bioscience from 2007-10 and since 2011, Deputy Dean and Associate Dean (Finance and Administration) in Sydney Medical School.
Research Interest
Professor Conigrave is interested in the links between nutrient-sensing receptors and the metabolic basis of health and disease with an emphasis on food intake and metabolic bone disease. His laboratory’s work focuses on a subgroup of the G-protein coupled receptor superfamily (‘class C’) that includes amino acid sensors involved in triggering gut digestive and hormonal regulatory responses. Having identified binding sites for the nutrient sensors on GPCR class C, his team is characterising the downstream signaling pathways and resultant biological effects. He also has extensively studied the parathyroid gland and mechanisms of parathyroid hormone (PTH) secretion control by the CaSR in normal glands and adenomatous disease in primary hyperparathyroidism.
Publications
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Gosby, A., Lau, N., Tam, C., Iglesias, M., Morrison, C., Caterson, I., Brand-Miller, J., Conigrave, A., Raubenheimer, D., Simpson, S. (2016). Raised FGF-21 and Triglycerides Accompany Increased Energy Intake Driven by Protein Leverage in Lean, Healthy Individuals: A Randomised Trial. PloS One, 11(8), 1-16.
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Solon-Biet, S., Cogger, V., Pulpitel, T., Heblinski, M., Wahl, D., McMahon, A., Warren, A., Durrant-Whyte, J., Walters, K., Krycer, J., Ponton, F., Gokarn, R., Wali, J., Conigrave, A., James, D., Raubenheimer, D., Le Couteur, D., Simpson, S., et al (2016). Defining the Nutritional and Metabolic Context of FGF21 Using the Geometric Framework. Cell Metabolism, 24(4), 555-565
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Quinn, S., Conigrave, A. (2003). Alternative agonists and modulators: evidence that the calcium-sensing receptor is a multi-modal sensor. In Chattopadhyay, Naibedya; Brown, Edward M (Eds.), Calcium-sensing Receptor, (pp. 203-226). Germany: Springer.
