Barry Slobedman
Professor
Immunology
University of Sydney
Australia
Biography
Associate Professor Barry Slobedman obtained both a BSc (with Honours) and a PhD in molecular virology from the University of Adelaide before moving to Stanford University (USA) where he trained as a post-doctoral research fellow at the Stanford University Medical Center in the Department of Microbiology and Immunology. He returned to Australia as a Rolf Edgar Lake Fellow and established an independent research group in 2000.
Research Interest
Associate Professor Barry Slobedman is head of the Cytomegalovirus (CMV) Research Group. Human CMV is a herpesvirus which infects a vast majority of the world¿s population, where it is a leading cause of opportunistic and congenital disease. Primary productive infection leads to a lifelong latent infection that is characterised by maintenance of the viral genome without infectious virus production. Periodically, the virus reactivates from latency and is shed in bodily secretions. Whilst primary and reactivated infections are usually mild or asymptomatic in healthy adults, primary infection is a major cause of serious congenital infection leading to still birth or neurological damage in children and reactivated infection is a major cause of life-threatening disease in immunosuppressed individuals, such as those with HIV AIDS and in allogeneic stem cell and solid organ transplant recipients.
Publications
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Low, H., Mukhamedova, N., Cui, H., McSharry, B., Avdic, S., Hoang, A., Ditiatkovski, M., Liu, Y., Fu, Y., Meikle, P., Slobedman, B., et al (2016). Cytomegalovirus Restructures Lipid Rafts via a US28/CDC42-Mediated Pathway, Enhancing Cholesterol Efflux from Host Cells. Cell Reports, 16(1), 186-200.
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Ashley, C., Glass, M., Abendroth, A., McSharry, B., Slobedman, B. (2017). Nuclear domain 10 components upregulated via interferon during human cytomegalovirus infection potently regulate viral infection. Journal of General Virology, 98(7), 1795-1805.
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Young, V., Mariano, M., Tu, C., Allaire, K., Avdic, S., Slobedman, B., Spencer, J. (2017). Modulation of the host environment by human cytomegalovirus with viral interleukin 10 in peripheral blood. The Journal of Infectious Diseases, 215(6), 874-882.