Damian Holsinger
Senior Lecturer
Neuroscience
University of Sydney
Australia
Biography
Damian Holsinger began investigating molecular mechanisms underlying Alzheimer's disease in 1997. In 2002 he made the seminal discovery that levels of the pivotal AD-related enzyme, BACE1, were increased in the brain of patients (Annals of Neurology, 51:783-786). These findings have been widely accepted in the field (483 citations) and have led to a concentrated focus on this enzyme as a therapeutic avenue for the treatment of Alzheimer's disease. In 2006, Damian accepted a position as Lecturer in Neuroscience at The University of Sydney and founded the Laboratory of Molecular Neuroscience and Dementia at the Brain & Mind Research Institute in 2007. He continues to investigate molecular mechanisms underlying neurodegenerative diseases with a particular focus on BACE1.
Research Interest
Research interests surround the understanding of mechanisms by which complex neurological disorders (with a special interest in Alzheimer's dsiease) arise and methods of treating these diseases.
Publications
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Thompson, G., Ireland, T., Larkin, X., Arnold, J., Holsinger, D. (2014). A Novel Segmentation-Based Algorithm for the Quantification of Magnified Cells. Journal Of Cellular Biochemistry, 115, 1849-1854
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Holsinger, D. (2015). Translation of low-risk dementia-associated interventions into practice- a call to action. Healthy Aging Research, 4(30), 1-9
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Rollo, J., Banihashemi, N., Vafaee, F., Crawford, J., Kuncic, Z., Holsinger, D. (2016). Unraveling the mechanistic complexity of Alzheimer's disease through systems biology. Alzheimer's and Dementia, 12(6), 708-718
