Nicholas Shackel
Professor
Medicine
University of Sydney
Australia
Biography
Dr Shackel is a clinical scientist with an established tract record in academia being the recipient of multiple awards including a NHMRC Gustav-Nossal Scholarship and a NHMRC C. J. Martin Fellowship. Dr Shackel has authored 78 publications.
Research Interest
To understand the molecular mechanisms regulating liver fibrosis aiming to developed novel therapeutic agents as well as developing new diagnostic investigations. The current focus of the research group is to further understand the role of the glycoprotein CD147 in mediating basic and fundamental aspects of tissue inflammatory responses and carcinogenesis. Our group has made the fundamental discovery that CD147 mediates a process of inflammatory cell aggregation, which was previously not recognised, that mediates inflammatory responses and carcinogenesis. Taking this novel discovery from the bench through to high impact papers is the current focus of the group.
Publications
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Tong, A., Sautenet, B., Chapman, J., Harper, C., Macdonald, P., Shackel, N., Crowe, S., Hanson, C., Hill, S., Synnot, A., Craig, J. (2017). Research priority setting in organ transplantation: A systematic review. Transplant International, 30(4), 327-343.
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Pulitano, C., Joseph, D., Sandroussi, C., Verran, D., Ho, P., Debiasio, A., Luongo, A., McCaughan, G., Shackel, N., Crawford, M. (2017). Postreperfusion microcirculatory derangements after liver transplantation: Relationship to hemodynamics, serum mediators, and outcome. Liver Transplantation, 23(4), 527-536.
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Tu, T., Budzinska, M., Shackel, N., Urban, S. (2017). HBV DNA integration: Molecular mechanisms and clinical implications. Viruses, 9(4), 1-18.
