Patrick Tam
Professor
Medicine
University of Sydney
Australia
Biography
Professor Patrick Tam is the Deputy Director and Head of the Embryology Research Unit at the Children's Medical Research Institute, Senior Principal Research Fellow of the National Health and Medical Research Council (NHMRC) of Australia and Professor in the School of Medical Sciences of Sydney Medical School at University of Sydney. Professor Tam is also the Mok Hing-Yiu Distinguished Visiting Professor at the School of Biomedical Sciences of University of Hong Kong.
Research Interest
Professor Tam's research focuses on the systems-based investigation of the gene regulatory network underpinning the cellular and molecular mechanisms of body patterning during mouse development and the biology of stem cells. He pioneered the application of micromanipulation and embryo culture for analyzing mouse embryos and examining the development of the head and embryonic gut. The embryological analysis undertaken by his team at CMRI has enabled the construction of a series of fate-maps revealing the organization of the basic body plan of the early embryo. The in-depth knowledge of cell differentiation during early embryogenesis laid the foundation for directing the differentiation of stem cells into clinically useful cell types for therapy in regenerative medicine
Publications
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Zamir, L., Singh, R., Nathan, E., Patrick, R., Yifa, O., Yahalom-Ronen, Y., Arraf, A., Schultheiss, T., Suo, S., Han, J., Tam, P., et al (2017). Nkx2.5 marks angioblasts that contribute to hemogenic endothelium of the endocardium and dorsal aorta. eLife, 6, 1-31.
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Rossant, J., Tam, P. (2017). New insights into early human development: lessons for stem cell derivation and differentiation. Cell Stem Cell, 20(1), 18-28.
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Fatima, S., Wagstaff, K., Lieu, K., Davies, R., Tanaka, S., Yamaguchi, Y., Loveland, K., Tam, P., Jans, D. (2017). Interactome of the inhibitory isoform of the nuclear transporter Importin 13. Biochimica et Biophysica Acta, 1864 (3), 546-561
