Tracy Bryan
Unit Head
Cell Biology
University of Sydney
Australia
Biography
Associate Professor Tracy Bryan obtained her Bachelor of Science degree from Macquarie University in Sydney. During herPhD studies with Roger Reddel at the Children’s Medical Research Institute (CMRI) in Sydney (1993 – 1997), she discovered a new mechanism for maintenance of the ends of chromosomes (telomeres) in human tumours, called ALT.
Research Interest
Telomerase is the enzyme responsible for lengthening the ends of chromosomes (telomeres), thereby allowing most cancer cells to divide indefinitely. We are determining the mechanisms of telomerase function using biochemical and cell-based approaches, with the aim of developing telomerase inhibitors as cancer therapeutics.
Publications
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Moye, A., Bryan, T. (2015). Proteins that interact with DNA and RNA G-quadruplexes. In David Monchaud (Eds.), Biological Relevance and Therapeutic Applications of DNA- and RNA-Quadruplexes, (pp. 101-117). London: Future Science Ltd. [More Information] Tomlinson, C., Cohen, S., Bryan, T. (2014). Inhibition of Telomerase: Promise, Progress and Potential Pitfalls. In Stephen Neidle (Eds.), Cancer Drug Design and Discovery, (pp. 491-527). London, United Kingdom: Academic Press. [More Information] Bryan, T. (2009). Telomeres and the End Replication Problem. In Lynne Cox (Eds.), Molecular Themes in DNA Replication, (pp. 217-268). RSC Publishing.
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Tomlinson, C., Cohen, S., Bryan, T. (2014). Inhibition of Telomerase: Promise, Progress and Potential Pitfalls. In Stephen Neidle (Eds.), Cancer Drug Design and Discovery, (pp. 491-527). London, United Kingdom: Academic Press
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Moye, A., Bryan, T. (2015). Proteins that interact with DNA and RNA G-quadruplexes. In David Monchaud (Eds.), Biological Relevance and Therapeutic Applications of DNA- and RNA-Quadruplexes, (pp. 101-117). London: Future Science Ltd.
