Mark Ambrose
Lecturer (Medical Microbiology)
Department of health
University of Tasmania
Australia
Biography
Before joining the University of Tasmania, he completed postdoctoral studies in DNA repair and mutagenesis at the Harvard School of Public Health (Harvard University), the Massachusetts Institute of Technology (MIT), and at the University of California, Los Angeles (UCLA).
Research Interest
Dr Ambrose's research focus is on DNA-damage signalling, DNA repair, and mutagenesis in bacteria, yeast and human model systems. In particular, his research emphasises the use of conventional mutation detection assays, along with whole genome and proteome interrogation methodologies, to investigate the impact of physiological stress on the activation and modulation of damage-inducible error-prone DNA repair pathways. His research aimed at understanding how bacteria develop antimicrobial resistance during colonisation of the lungs of people with cystic fibrosis (CF) is aligned to the University's research theme of Better Health.
Publications
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Ambrose M, Goldstine JV, Gatti RA. Intrinsic mitochondrial dysfunction in ATM-deficient lymphoblastoid cells. Human molecular genetics. 2007 Jul 2;16(18):2154-64.
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Hofseth LJ, Khan MA, Ambrose M, Nikolayeva O, Xu-Welliver M, Kartalou M, Hussain SP, Roth RB, Zhou X, Mechanic LE, Zurer I. The adaptive imbalance in base excision–repair enzymes generates microsatellite instability in chronic inflammation. Journal of Clinical Investigation. 2003 Dec 15;112(12):1887.
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Horowitz E, Ambrose M, Fetta M, Hakim S, Kaufman M, Robinson D, inventors; Citibank, NA, assignee. Automated system and method for customized and personalized presentation of products and services of a financial institution. United States patent US 6,349,290. 2002 Feb 19.
