Harald Sitte

Biography

Dr. Harald Sitte is currently working as a Professor in the Department of Center for Physiology and Pharmacology (Institute of Pharmacology), Medical University of Vienna ,  Austria. His research interests includes Physiology and Pharmacology. He /she is serving as an editorial member and reviewer of several international reputed journals. Dr. Harald Sitte is the member of many international affiliations. He/ She has successfully completed his Administrative responsibilities. He /she has authored of many research articles/books related to Physiology and Pharmacology.

Research Interest

Neurotransmitters transporters are located in presynaptic specializations. They inactivate neurotransmitter-mediated neurotransmission following exocytotic release by a simple reuptake mechanism. Recent crystallographic examination of bacterial homologs to mammalian neurotransmitter transporters provides a structural scaffold which supports transport by an alternative access mechanism. Monoamine transporters are a target of clinically relevant drugs: (i) antidepressants competitively block the reuptake of monoamines. Thereby, these compounds enhance the extracellular monoamine concentration which is relevant for clinical success. (ii) amphetamines and cathinones, which behave as substrates of the transporters, trigger non-exocytotic neurotransmitter release (efflux). The exact molecular mechanism of the psychostimulant action, however, still remains enigmatic.