Alexander Stark
Senior Scientist
Molecular & Cellular Biology
Research Institute of Molecular Pathology
Austria
Biography
Dr. Alexander Stark is a Senior Scientist of Department of Molecular & Cellular Biology at Research Institute of Molecular Biology, Austria.
Research Interest
The regulation of gene expression in response to developmental or environmental stimuli is a crucial mechanism in all organisms. We are fascinated by the question how transcription is regulated at the level of enhancer and core-promoter DNA elements, and the transcription factor and cofactor proteins that mediate transcription activation. We use genome-wide functional assays, bioinformatics, and mass-spectrometry; and develop highly-controllable reporter assays that provide direct functional readouts. Our goal is to understand transcription and – ultimately – how transcriptional networks define cellular and developmental programs.
Publications
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Kvon, EZ., Kazmar, T., Stampfel, G., Yáñez-Cuna, JO., Pagani, M., Schernhuber, K., Dickson, BJ., Stark, A. (2014). Genome-scale functional characterization of Drosophila developmental enhancers in vivo. Nature. 512(7512):91-5
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Zabidi MA, Arnold CD, Schernhuber K, Pagani M, Rath M, et al., (2015) Enhancer-core-promoter specificity separates developmental and housekeeping gene regulation. Nature. 518:556-9
