Tim Clausen
Senior Scientist
Molecular & Cellular Biology
Research Institute of Molecular Pathology
Austria
Biography
Dr. Tim Clausen is a Senior Scientist of Department of Molecular & Cellular Biology at Research Institute of Molecular Biology, Austria.
Research Interest
All cells have evolved a sophisticated protein quality control system by which molecular chaperones and proteases monitor the functionality of each protein, thus reducing the amount of misfolded molecules that may undergo dangerous interactions. Our group performs a structure-function analysis of several eukaryotic and prokaryotic quality control factors with the purpose of disclosing novel strategies to combat protein-folding diseases and bacterial pathogenicity.
Publications
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Gazda, L., Pokrzywa, W., Hellerschmied, D., Löwe, T., Forné, I., Mueller-Planitz, F., Hoppe, T., Clausen, T. (2013). The myosin chaperone UNC-45 is organized in tandem modules to support myofilament formation in C. elegans. Cell. 152(1-2):183-95
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Schmidt, A., Trentini, DB., Spiess, S., Fuhrmann, J., Ammerer, G., Mechtler, K., Clausen, T. (2014). Quantitative phosphoproteomics reveals the role of protein arginine phosphorylation in the bacterial stress response. Mol Cell Proteomics. 13(2):537-50
