Zhe-sheng Jason Chen
Chair, Division of Adult and Geriatric Health
Department of Patient Care
Union Graduate College
Dr. Chen has recieved his MS degree in Biochemical Pharmacology/Toxicology from Sun YatSen University China,MD degree from Guangdong Medical and Pharmaceutical College China, Ph D degree in Cancer Pharmacology from Kagoshima University School of Medicine Japan, Postdoctoral training at Kagoshima University Japan, another Postdoctoral training in the Department of Medical Oncology Fox Chase Cancer Center Philadelphia. He started his professional career as Assistant professor at St. John\\\\s University in 2004. After that he worked as Associate professor at St.John\\\\s University in 2008.His research effortsare enclosed in Cancer Pharmacology and Experimental Therapeutics especially focusing on cellular mechanisms of multidrug resistance MDR. He has been involved in the research of most of the multidrug resistance proteins MRPs and have published ~60 publications in peerreviewed Journals for the last 10 years. He teaches Biochemistry Pharmacology Oncology at St John\\\\s University. He is a reviewer of 33 journals including International Journals and an editorial board member of 10 journals.
My laboratory is interested in the molecular and cellular pharmacology of anticancer drugs, such as drug resistance mechanisms and reversal of resistance study and new drug development. A promise of our research program is that progress in the chemotherapy of cancer will depend on rational combination of agents that reduce the function of plasma membrane transporters (ATP-binding cassette trasnporters) such as P-gp, ABCG2 and MRPs, and to enhance the actions of cytotoxic drugs. In collaboration with many researchers in USA, China, Japan, Australia and Egypt, studies in our laboratory focus on screening and identifying new inhibitors of ABC transporters by in vitro membrane vesicles transport assay system and cell based assay systems. Another future research direction is to study the role of MRP family on the detoxification of chemicals using knock out mouse models.