Department of Cardiology
Fabien Gosselet is researcher at the Bloodbrain barrier BBB laboratory directed by Professor Romeo Cecchelli and located at the faculty of Lens France. His Ph.D. thesis in the biggest cancer hospital in Europe the Gustave Roussy Institute in Villejuif France have consisted to characterize involvement of the Bone Morphogenetic Protein BMP signalling pathway in normal human skin keratinocytes and in tumorigenesis processes Since 2006 he has focused his research activity on the physiology of the endothelial cells and pericytes both composing the BloodBrain Barrier in normal and pathological conditions ie Alzheimer disease. Using an original model consisting to cultivate bovine brain capillary endothelial cells with new born rat glial cells his team studies the transport of A Beta peptides across the BBB and the relationship between brain cholesterol metabolism and Alzheimer disease
Fabien has focused his research activity on the Blood brain barrier physiology in normal and pathological conditions, In vitro and in vivo Blood brain barrier models, Transport of molecules across the Blood brain barrier, Astroglia endothelial interrelations, Cerebral cholesterol metabolism and Blood brain barrier, Biochemistry and signaling pathways at the BBB level, Skin homeostasis and cancerology.