Immunology
Global

Immunology Experts

Andreas Reimold, M.d.

Independent Director and Chairman of Nomination Co
immunology
UT Southwestern Medical Center
Bahrain

Biography

The focus of the Reimold lab's research program is to understand how transcription factors control the expression of genes involved in inflammation. Insights into how these proteins turn genes on and off may lead to new treatments for rheumatic diseases. They have studied transcription factors binding to DNA at cyclic AMP response elements, a sequence of widespread importance in the regulation of proinflammatory genes. To determine the precise functions of these transcription factors, mice with targeted disruptions of the genes under study were generated and have revealed defects in embryonic growth and development, as well as impaired activation of inflammatory pathways. Recently they have identified a block in the pathway of B lymphocyte terminal differentiation in one of our knockout mouse models. Further work will help to elucidate how the interaction of transcription factors with each other and with their target genes regulates the production of immunoglobulin-secreting plasma cells.   Education Medical School Columbia University College of Physicians and Surgeons (1984) Internship/Residency Washington University School of Medicine (1987), Internal Medicine Fellowship Harvard Medical School (1991), Rheumatology Fellowship Harvard Medical School (1993), Immunology Clinical Interest Rheumatoid Arthritis Spondyloarthropathy Systemic Lupus Erythematosus Myositis Sjogren's Syndrome Systemic Sclerosis Vasculitis Relapsing Polychondritis IGG4 Related Disease Crystalline Arthropathies Osteoarthritis Sarcoidosis Polymyalgia Rheumatic Interstitial Lung Disease (Pulmonary Fibrosis) Scleroderma Research Interest Mechanisms of B cell differentiation Transcriptional regulation of lymphocyte function Publications Featured Publications New indications for treatment of chronic inflammation by TNFa blockade Reimold, A.M. American Journal of Medical Science 2003 325 75-92 Plasma cell differentiation requires the trasncription factor XBP-1 Reimold A.M., N.N. Iwakoshi, J. Manis, P. Vallabhajosyula, E. Szomolanyi-Tsuda, E.M. Gravallese, D. Friend, M.J. Grusby, F. Alt, L.H. Glimcher Nature 2001 412 300-307 An essential role in liver development for transcription factor XBP-1 Reimold A.M., A. Etkin, I Clauss, A. Perkins, D.S. Friend, J. Zhang, H.F. Horton, A. Scott, S. Orkin, M.C. Byrne, M.J. Grusby, L.H. Glimcher Genes and Development 2000 14 152-157 Results 1-3 of 3 1 Honors & Awards Lyndon Baines Johnson Research Award American Heart Association (2002) Arthritis Investigator Award American College of Rheumatology (1997) Professional Associations/Affiliations American Association of Immunologists American College of Rheumatology Arthritis Foundation New Patient Appointments Dallas: 214-645-8300 Fort Worth: 817-882-2700 Book an Appointment Quick Links Refer a patient Existing patients/MyChart Find a location Clinics Internal Medicine Subspecialties Clinic 5303 Harry Hines Blvd. 8th Floor, Suite 400 Dallas, Texas 75390-8872 214-645-2800 Related Links Rheumatic Diseases Division Institution Careers Comments & Questions Contact Us Maps Sitemap Legal Non-Discrimination Policy Patient Rights Open Records Privacy Policy Site Policies State State of Texas Texas Veterans Portal TRAIL Search UT System Social               Copyright 2017. The University of Texas Southwestern Medical Center 5323 Harry Hines Blvd., Dallas, Texas 75390 Phone 214-648-3111

Research Interest

The focus of the Reimold lab's research program is to understand how transcription factors control the expression of genes involved in inflammation. Insights into how these proteins turn genes on and off may lead to new treatments for rheumatic diseases. They have studied transcription factors binding to DNA at cyclic AMP response elements, a sequence of widespread importance in the regulation of proinflammatory genes. To determine the precise functions of these transcription factors, mice with targeted disruptions of the genes under study were generated and have revealed defects in embryonic growth and development, as well as impaired activation of inflammatory pathways. Recently they have identified a block in the pathway of B lymphocyte terminal differentiation in one of our knockout mouse models. Further work will help to elucidate how the interaction of transcription factors with each other and with their target genes regulates the production of immunoglobulin-secreting plasma cells.   Education Medical School Columbia University College of Physicians and Surgeons (1984) Internship/Residency Washington University School of Medicine (1987), Internal Medicine Fellowship Harvard Medical School (1991), Rheumatology Fellowship Harvard Medical School (1993), Immunology Clinical Interest Rheumatoid Arthritis Spondyloarthropathy Systemic Lupus Erythematosus Myositis Sjogren's Syndrome Systemic Sclerosis Vasculitis Relapsing Polychondritis IGG4 Related Disease Crystalline Arthropathies Osteoarthritis Sarcoidosis Polymyalgia Rheumatic Interstitial Lung Disease (Pulmonary Fibrosis) Scleroderma Research Interest Mechanisms of B cell differentiation Transcriptional regulation of lymphocyte function Publications Featured Publications New indications for treatment of chronic inflammation by TNFa blockade Reimold, A.M. American Journal of Medical Science 2003 325 75-92 Plasma cell differentiation requires the trasncription factor XBP-1 Reimold A.M., N.N. Iwakoshi, J. Manis, P. Vallabhajosyula, E. Szomolanyi-Tsuda, E.M. Gravallese, D. Friend, M.J. Grusby, F. Alt, L.H. Glimcher Nature 2001 412 300-307 An essential role in liver development for transcription factor XBP-1 Reimold A.M., A. Etkin, I Clauss, A. Perkins, D.S. Friend, J. Zhang, H.F. Horton, A. Scott, S. Orkin, M.C. Byrne, M.J. Grusby, L.H. Glimcher Genes and Development 2000 14 152-157 Results 1-3 of 3 1 Honors & Awards Lyndon Baines Johnson Research Award American Heart Association (2002) Arthritis Investigator Award American College of Rheumatology (1997) Professional Associations/Affiliations American Association of Immunologists American College of Rheumatology Arthritis Foundation New Patient Appointments Dallas: 214-645-8300 Fort Worth: 817-882-2700 Book an Appointment Quick Links Refer a patient Existing patients/MyChart Find a location Clinics Internal Medicine Subspecialties Clinic 5303 Harry Hines Blvd. 8th Floor, Suite 400 Dallas, Texas 75390-8872 214-645-2800 Related Links Rheumatic Diseases Division Institution Careers Comments & Questions Contact Us Maps Sitemap Legal Non-Discrimination Policy Patient Rights Open Records Privacy Policy Site Policies State State of Texas Texas Veterans Portal TRAIL Search UT System Social               Copyright 2017. The University of Texas Southwestern Medical Center 5323 Harry Hines Blvd., Dallas, Texas 75390 Phone 214-648-3111

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