Chemistry
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Chemistry Experts

Sergey A. Usanov

Director
BioOrganic Chemistry
State Scientific Institution THE INSTITUTE OF BIOORGANIC CHEMISTRY
Belarus

Biography

 Qualifications Doctor of the Chemical Sciences (since 1990), Professor (2003). Corresponding Member of the National Academy of Sciences of Belarus. Elected in 2004 on specialty Bioorganic Chemistry. Membership of other Academies, Scientific Societies and Councils Member of the Scientific Council of the Institute of Bioorganic Chemistry National Academy of Sciences of Belarus, Member of the Scientific Doctorate Degree Council at the Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus Training 1993-1995 - Professor of the National Institute of Environmental Health Sciences (NIEHS, Research Triangle Park, North Carolina, USA). 1997-2001 - Professor of the Department of Biochemistry, University of Texas Southwestern Medical Center (Dallas, Texas, USA). 2003-2004 - Professor of the Medical Center at Osaka University (Osaka, Japan).

Research Interest

 Research interests in bioorganic chemistry, biotechnology and molecular biology. Structure and function of the cytochrome P450 dependent monooxygenase systems involved in biosynthesis of physiologically active bioregulators and xenobiotics metabolism. Elucidation of the molecular mechanisms of some inherited diseases connected with disturbances of steroid hormone biosynthesis and hormonal regulation.

Publications

  • Usanov S.A., Gilep A.A., Lepesheva G.I., Strushkevich N.V., Azeva T.N., Graham S., Peterson J.A., Estabrook R.W. Probing the interaction of cytochrome P450scc (CYP11A1) with adrenodoxin: evaluating site-directed mutations by molecular modeling // Biochemistry. 2002, Vol.41, No.26, P.8310-20

  • Gilep A.A., Guryev O.L., Usanov S.A., Estabrook R.W. Expression, purification and physical properties of recombinant flavocytochrome fusion proteins containing rat cytochrome b5 linked to NADPH-cytochrome P450 reductase by different membrane-binding segments // Arch. Biochem. Biophys. 2001, Vol.390, No.2, P.222-234.

  • Guryev O.L., Gilep A.A., Usanov S.A., Estabrook R.W. Interaction of apo-cytochrome b5 with cytochromes P4503A4 and P45017A. Relevance of heme transfer reactions // Biochemistry. 2001, Vol.40, P.5018-5031.

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