Monica Gordon-alonso

Biography

My host laboratory has reported that treating human tumor-infiltrating lymphocytes with galectin antagonists or an anti-galectin-3 antibody boosts the secretion of cytokines upon stimulation. Extracellular galectins are involved in fibrosis, inflammation and cancer. I am examining in tumors whether galectins sequester glycosylated soluble factors at the extracellular matrix, such as interleukins and chemokines, impairing immune cell communication and recruitment. I am also assessing in different human inflammatory pathologies whether galectins affect immune dysfunction. I focus on pathologies where galectins could be found together with activated T lymphocytes, such as Crohn’s disease and arthritis. I will study how galectins regulate T cells, macrophages and fibroblasts in these diseases.

Research Interest

Tumor, immunology, cancer genetics