Rubem Figueiredo Sadok
Researcher
Parasitology
Oswaldo Cruz Institute- Fiocruz
Brazil
Biography
Bachelor's degree in Biological Sciences from Santa Úrsula University (2003), Master's degree (2006) and PhD (2008) in Cellular and Molecular Biology, IOC, Oswaldo Cruz Foundation, postdoctoral degree from the Institute of Medical Biochemistry, Federal University of Rio de Janeiro. He is currently a researcher at the Oswaldo Cruz Foundation, a level 2 productivity grant from CNPq and a Young Scientist from Our State by FAPERJ. He is permanent advisor of the Graduate in Cellular and Molecular Biology, IOC, and postgraduate collaborator in Parasitary Biology. He has experience in the area of ​​Parasitology, with emphasis on Parasitic Animal Protozoology, acting mainly on the following subjects: Trypanosoma cruzi, chemotherapy, Chagas' disease, electron microscopy, high resolution oxigraphy, cell death, autophagy, mitochondria, oxidative stress and naftoquinones.
Research Interest
Trypanosoma cruzi, chemotherapy, Chagas' disease, electron microscopy, high resolution oxigraphy, cell death, autophagy, mitochondria, oxidative stress and naftoquinones.
Publications
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FONSECA-SILVA, F. ; CANTO-CAVALHEIRO, M. M. ; Menna-Barreto, R.F.S. ; ALMEIDA-AMARAL, E. E. . Oral Efficacy of Apigenin against Cutaneous Leishmaniasis: Involvement of Reactive Oxygen Species and Autophagy as a Mechanism of Action. PLoS Neglected Tropical Diseases (Online), v. 10, p. e0004442, 2016.
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NOGUEIRA, N. P. A. ; SARAIVA, F. M. S. ; OLIVEIRA, M. P. ; MENDONCA, A. P. M. ; INACIO, J. D. F. ; ALMEIDA-AMARAL, E. E. ; Menna-Barreto, R.F.S. ; LARANJA, G A T ; TORRES, E. L. ; OLIVEIRA, M. F. ; PAES, M. C. . Heme modulates Trypanosoma cruzi bioenergetics inducing mitochondrial ROS production. Free Radical Biology & Medicine, p. 183-191, 2017.
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SILVA, A. M. ; ARAUJO-SILVA, L. ; BOMBACA, A. C. S. ; Menna-Barreto, R.F.S. ; RODRIGUES-SANTOS, C. E. ; FERREIRA, A. B. B. ; DECASTRO, Solange Lisboa . Synthesis and biological evaluation of N-alkyl naphthoimidazoles derived from β-lapachone against Trypanosoma cruzi bloodstream trypomastigotes. MedChemComm, v. 8, p. 952-959, 2017.
