Cesar Seigifuziwara
Professor
Department of Cell and Developmental Biology
University of Sao Paulo
Brazil
Biography
Cesar SeigiFuziwara did Master's and PhD in Sciences by the Institute of Biomedical Sciences of the University of São Paulo, Department of Cellular Biology and Development.
Research Interest
Its research line seeks to understand the control of activation / inhibition of microRNA expression (miR-17-92 and let-7) during thyroid oncogenesis (BRAF, RAS and RET / PTC), as well as the involvement of long-non coding RNAs (lncRNAs) in this process. As a methodological tool, it studies the applicability of gene editing therapy via CRISP / CAS9 to interrupt the expression of oncogenic microRNAs. In addition to regulatory RNAs, it studies the role of novel oncogenic proteins such as FAM83F and LIN28 in cancer progression. He is involved in projects that cover the study of the effect of excess iodine on the expression of genes involved in oxidoreduction, standardization of methodologies for the detection of mutations in the BRAF gene (RFLP-PCR, SSCP) and RAS, Tissue micro-array (TMA) for immunohistochemical analysis. (Source: Curriculum Lattes)
