Dr. Hoang-thanh Le
PhD
Organic Chemistry
Advanced Medical Research Institute of Canada
Canada
Biography
Dr. Le received his Ph.D. in Organic Chemistry from the University of Paris-Sud, France in 1996 after completing his chemistry degree from Humboldt University in Berlin, Germany. Following Post-Doctoral Fellowships (1996 to 1999) at the Institute for the Chemistry of Natural Substances, Gif-sur-Yvette, France and in the Department of Cellular and Molecular Medicine and the University of Ottawa, Faculty of Medicine, Dr. Le continued to work at the University of Ottawa as a Research Associate. In 2005, he moved to the Regenerative Medicine program at the Ottawa Hospital Research Institute (OHRI). He joined Variation Biotechnologies Inc. (VBI company) in 2007 as a Peptide Scientist and was promoted to Formulation Team Leader one year later. Dr. Le joined the Vaccine Development and Immunology Department at Health Sciences North Research Institute in 2011.
Research Interest
Dr. Le’s expertise are in the development of new immunotherapy strategies for invention and treatment of drug addiction and new mucosal adjuvant approach in treatment of chronic disease. Chronic diseases, including diabetes, obesity, and heart disease, have high potential impacts not only in developed countries, but also in low and middle income countries.
Publications
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René Poirier, Irma Lemaire, Michel Dumont, Natacha Leduc, Hoang-Thanh Le, and Simon Lemaire. Correlation between the expression of the histone H4 mRNA variant H4-v.1 and the levels of the C-terminal histone H4 peptides OGP and H4-(86-100) in various rat tissues and isolated alveolar macrophages. Peptides. (2005), 26, 1503-1511.
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Lemaire, Simon, Trinh, TT, Le, Hoang-Thanh, Tang, SC, Hincke, M, Wellman-Labadie O, Ziai, S. Antimicrobial effects of H4-(86-100), histogranin and related compounds - possible involvement of DNA gyrase. The FEBS Journal (2008), 275, 5286-5297.
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Azizi* A, Ghunaim H, Sirskyj D, Fallahi F, Le* H.-T. and Kumar A. Delivery of immunogens to mucosal immune system using an oral inactivated cholera vaccine: A new approach for development of oral vaccines. Human vaccines and Immunotherapeutics (2013), 9, 1-4.
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Trần Khánh Linh, Nguyá»…n Thị Yến Nhi, Lê Hà Tầm DÆ°Æ¡ng, Äặng Trịnh Minh Anh, Francisco Diaz-Mitoma, Hoang-Thanh Le*, Cao Thị Bảo Vân*. Initial Evaluation of Immunogenicity and Safety of Intranasal Nicotine Vaccine on Animal Models. Journal of Preventive Medicine (2015), 165, 360-365
