Adam J. Macneil
Assistant Professor
Faculty of Applied Health Sciences
Brock University
Canada
Biography
Breathe easier! Dr. MacNeil’s research team is investigating novel approaches toward understanding and blocking allergic inflammation caused by chronicpathologies, including asthma, hives, rhinitis, and food allergies. Dr. MacNeil’s Inflammation & Immunity Lab, located in the Cairns Complex, employs innovative biomedical methods and technologies permitting studies from the whole organism-level down to the fundamental genetic, molecular, and cellular building blocks directing uncontrolled inflammatory responses to allergens. Dr. MacNeil believes basic science discoveries feed clinical and translational approaches to a healthier future.
Research Interest
Identification of novel targets and innovative therapies in allergic inflammation, Epigenetic control of mast cell differentiation from stem cells, Cell signaling mechanisms in innate immune cell development and activation, Interdisciplinary collaborations exploring the role of immunity in the nervous and cardiovascular systems with links to biological and social outcomes
Publications
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Wu, Z., MacNeil, A.J.*, Junkins, R., Li B., Berman J.N., and T.J. Lin*. 2013. Mast cell FcεRI-induced early growth-response 2 regulates CCL1-dependent CD4+ T cell migration. Journal of Immunology 190(9): 4500-4507.
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Wu Z., MacNeil, A.J., Berman J.N., and T.J. Lin. 2013. Syntaxin binding protein 1 is not required for allergic inflammation via IgE-mediated mast cell activation. PLoS One 8(3): e58560.
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Junkins R.D., MacNeil, A.J., Wu Z., McCormick C., and T.J. Lin. 2013. Regulator of calcineurin 1 suppresses inflammation during respiratory tract infections. Journal of Immunology 190(10): 5178-5186.
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Wu, Z., Li, Y., MacNeil, A.J., Junkins, R.D., Berman, J.N., and T.J. Lin. 2013. Calcineurin-Rcan1 interaction contributes to stem cell factor-mediated mast cell activation. Journal of Immunology 191(12): 5885-94.
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MacNeil, A.J., Junkins, R.D., Wu, Z., and T.J. Lin. 2014. Stem cell factor induces AP-1-dependent mast cell IL-6 production via MAPK kinase 3 activity. Journal of Leukocyte Biology 95(6): 903-915.
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Tompkins, N.*, MacNeil, A.J.*, and B. Pohajdak. 2014. Cytohesin-associated scaffolding protein (CASP) is a substrate for granzyme B and ubiquitination.Biochemical and Biophysical Research Communications 452(3): 473-478. * equal contribution
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Yang, T., Xie, Z., Li, H., MacNeil, A.J., Tremblay, M., Tang, J.T., and T.J. Lin. 2016. Protein tyrosine phosphatase 1B (PTP1B) suppresses IgE-mediated signal transducer and activator of transcription 5 (STAT5) phosphorylation in mast cells, but is dispensable for IgE-mediated cutaneous reaction in vivo. Cellular Immunology: S0008-8749(16): 30035-1.
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Moore, J., Megaly, M., MacNeil, A.J., Klentrou, P., and E. Tsiani. 2016. Rosemary extract reduces Akt/mTOR/p70S6K activation and inhibits proliferation and survival of A549 human lung cancer cells. Biomedicine & Pharmacotherapy306-307: 9-16.
