Adonis Skandalis
Associate Professor
Biological Sciences
Brock University
Canada
Biography
Dr. Adonis Skandalis is affiliated to Biological Sciences, Brock University, where Dr. Adonis Skandalis is currently working as Associate Professor. Dr. Adonis Skandalis has authored and co-authored several national and international publications and also working as a reviewer for reputed professional journals. Dr. Adonis Skandalis is having an active association with different societies and academies around the world. Dr. Adonis Skandalis made his mark in the scientific community with the contributions and widely recognition from honourable subject experts around the world. Dr. Adonis Skandalis has received several awards for the contributions to the scientific community. Dr. Adonis Skandalis major research interest involves The major focus of my research has been the elucidation of mutagenic pathways that corrupt genetic information as it is being transmitted either by DNA replication or by transcription and protein synthesis. Research projects currently underway in my lab include: 1. Investigations of the spontaneous fidelity of mRNA splicing in humans and how it varies with age or disease. 2. Investigations of cell defense pathways against aberrant transcripts. 3. Survey of aberrant splicing using DNA microarray technology. 4. Directed evolution investigation to elucidate the structure-function relationships of enzymes involved in the metabolism of DNA and RNA, such as replication, repair, and splicing..
Research Interest
The major focus of my research has been the elucidation of mutagenic pathways that corrupt genetic information as it is being transmitted either by DNA replication or by transcription and protein synthesis. Research projects currently underway in my lab include: 1. Investigations of the spontaneous fidelity of mRNA splicing in humans and how it varies with age or disease. 2. Investigations of cell defense pathways against aberrant transcripts. 3. Survey of aberrant splicing using DNA microarray technology. 4. Directed evolution investigation to elucidate the structure-function relationships of enzymes involved in the metabolism of DNA and RNA, such as replication, repair, and splicing.
Publications
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Nadon, R., P Shi, A Skandalis, E Woody, H Hubschle, E Susko, N Rghei, and P Ramm. 2001. Statistical inference methods for gene expression arrays. Proceedings of BIOS 2001 International Biomedical Optics Symposium. San Jose, CA. 4266:46-55
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Skandalis A and LA Loeb. 2001. Enzymatic properties of rat DNA polymerase beta mutants obtained by randomized mutagenesis. Nucleic Acids Research 29:2418-2426.
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A. Skandalis, P.J.Ninniss, D. McCormac, and L. Newton. 2002. Spontaneous frequency of exon skipping in the human HPRT gene. Mutation Research. In Press
