Evengelia Litsa Tsiani
Associate Professor
Health Sciences
Brock University
Canada
Biography
My research focus is understanding the intracellular signaling pathways that are activated and control muscle glucose transport, metabolism and the defects contributing to insulin resistance/diabetes. An additional research focus is understanding cancer biology and the defects leading to enhanced cell proliferation. My goal/aim is to find food components, nutraceuticals, or functional foods that could modulate certain signaling pathways and be used against insulin resistance /diabetes and cancer.
Research Interest
Cell signaling; Insulin resistance; Muscle metabolism; Cell signaling pathways in cancer; Investigation of the biological effects of food components
Publications
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torozhuk Y, Hopmans SN, Sanli T, Barron C, Tsiani E, Cutz JC, Pond G, Wright J, Singh G, Tsakiridis T. Metformin inhibits growth and enhances radiation response of non-small cell lung cancer (NSCLC) through ATM and AMPK. Br J Cancer. 2013 Apr 30.
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Barron CC, Moore J, Tsakiridis T, Pickering G, Tsiani E. Inhibition of human lung cancer cell proliferation and survival by wine. Cancer Cell Int. 2014 Jan 23;14(1):6
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Mezil YA, Allison D, Kish K, Ditor D, Ward WE, Tsiani E, Klentrou P. Response of Bone Turnover Markers and Cytokines to High-Intensity Low-Impact Exercise.Med Sci Sports Exerc. 2015 Jul;47(7):1495-502.
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Naimi M, Tsakiridis T, Stamatatos TC, Alexandropoulos DI, Tsiani E. Increased skeletal muscle glucose uptake by rosemary extract through AMPK activation.Appl Physiol Nutr Metab. 2015 Apr;40(4):407-13.
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Moore J, Pickering G, Gaudette NJ, Tsiani E. Resveratrol-fortification of red wine does not provide greater inhibition of human lung cancer cell survival compared to non-fortified wine. Journal of Molecular Biochemistry, Vol 4, No 3 (2015)
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Pereira S, Park E, Moore J, Faubert B, Breen D, Oprescu A, Nahle A, Kwan D, Giacca A, Tsiani E. Resveratrol Prevents Insulin Resistance Caused by Short-Term Elevation of Free Fatty Acids In Vivo. Appl Physiol Nutr Metab. 2015 Published on the web 10 July 2015,
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Pereira S, Yu W Q, Moore J, Mori Y, Tsiani E, and Giacca A. Effect of a p38 MAPK inhibitor on FFA-induced hepatic insulin resistance in vivo. Nutrition & Diabetes, 2016 May 2;6:e210
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Barron CC, Bilan PJ, Tsakiridis T, Tsiani E. Facilitative glucose transporters: Implications for cancer detection, prognosis and treatment. Metabolism. 2016 Feb;65(2):124-39.
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Moore J, Megaly M, MacNeil AJ, Klentrou P, Tsiani E. Rosemary extract reduces Akt/mTOR/p70S6K activation and inhibits proliferation and survival of A549 human lung cancer cells. Biomed Pharmacother. 2016 Jul 28;83:725-732.
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Jessy Moore, Michael Yousef, Evangelia Tsiani. Anticancer Effects of Rosemary (Rosmarinus Officinalis L.) Extract and Rosemary Extract Polyphenols. Nutrients. 2016 Nov 17;8(11). pii: E731.
