Jeff Stuart
Associate Professor
Biological Sciences
Brock University
Canada
Biography
Dr. Jeff Stuart is affiliated to Biological Sciences, Brock University, where Dr. Jeff Stuart is currently working as Associate Professor. Dr. Jeff Stuart has authored and co-authored several national and international publications and also working as a reviewer for reputed professional journals. Dr. Jeff Stuart is having an active association with different societies and academies around the world. Dr. Jeff Stuart made his mark in the scientific community with the contributions and widely recognition from honourable subject experts around the world. Dr. Jeff Stuart has received several awards for the contributions to the scientific community. Dr. Jeff Stuart major research interest involves Animal lifespans range widely, from several days to over a century, yet the underlying reasons for these vast differences remain poorly understood. The goal of my research program is to gain a better understanding of the molecular mechanisms underlying longevity. Mitochondria, via their contribution to energy metabolism, cell death pathways, and redox regulated signal transduction pathways, are thought to be important effectors of longevity. We use a comparative approach to study these in mammalian species, including those that are exceptionally long-lived. We are also exploring the ability of small molecules including selective estrogen receptor modulators and phytoestrogens to modulate mitochondrial function and affect aging and longevity..
Research Interest
Animal lifespans range widely, from several days to over a century, yet the underlying reasons for these vast differences remain poorly understood. The goal of my research program is to gain a better understanding of the molecular mechanisms underlying longevity. Mitochondria, via their contribution to energy metabolism, cell death pathways, and redox regulated signal transduction pathways, are thought to be important effectors of longevity. We use a comparative approach to study these in mammalian species, including those that are exceptionally long-lived. We are also exploring the ability of small molecules including selective estrogen receptor modulators and phytoestrogens to modulate mitochondrial function and affect aging and longevity.
Publications
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Robb, E.L., Maddalena, L.A., Dunlop, V.A., Foster, T. and Stuart, J.A., 2012. Absence of metabolic rate allometry in an ex vivo model of mammalian skeletal muscle. Comp. Biochem. Physiol. 162,157-162.
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Stuart, J.A., Liang, P., Luo, X., Page, M.M., Gallagher, E.J., Christoff, C.A. and Robb, E.L., 2013. A Comparative Cellular and Molecular Biology of Longevity Database. Age. 35,1937-1947.
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Robb, E.L. and Stuart, J.A., 2014. The stilbenes resveratrol, pterostilbene and piceid affect growth and stress resistance in mammalian cells via a mechanism requiring estrogen receptor beta and the induction of Mn-superoxide dismutase. Phytochemistry, 98,164-173.
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Page, M.M., Sinclair, A., Robb, E.L., Stuart, J.A., Withers, D.J., Selman, C., 2014 Fibroblasts derived from long-lived insulin receptor substrate 1 null mice are not resistant to multiple forms of stress. Aging Cell 13(5), 962-964.
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Robb, E.L, Christoff, C.A., Maddalena, L.A., and Stuart, J.A., 2014. Mitochondrial reactive oxygen species in animal cells: relevance to aging and normal physiology. Can. J. Zool. 92(7): 603-613.
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Stuart, J.A., Maddalena, L.A., Merilovich, M., and Robb, E.L., 2014. A Midlife Crisis for the Mitochondrial Free Radical Theory of Aging. Healthspan and Longevity. 3(1):4.
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Yalagala, R.S., Mazinani, S.A., Maddalena, L.A., Stuart, J.A., Yan, F., Yan, H. 2016. Microwave-assisted syntheses of BODIPY-sugar conjugates through click chemistry and conjugate assembly into liposomes. Carbohydr Res. 2016 Apr 7;424:15-20.
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Maddalena, L.A, Ghelfi, M., Atkinson, J., Stuart, J.A., 2017. The mitochondria-targeted imidazole substituted oleic acid ‘TPP-IOA’ affects mitochondrial bioenergetics and its protective efficacy in cells is influenced by cellular dependence on aerobic metabolism. Biochim Biophys Acta. 1858:73-85.
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Robb, E.L., Moradi, F., Maddalena, L.A., Valente, A., Fonseca, J., Stuart, J.A., 2017 Resveratrol stimulates mitochondrial fusion by a mechanism requiring mitofusin-2. Biochem Biophys Res Commun, In Press.
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Valente, A.J.F., Maddalena, L.A., Robb, E.L., Moradi, F., Stuart, J.A., 2017. A Simple ImageJ Macro Tool for Analyzing Mitochondrial Network Morphology in Mammalian Cell Culture. Acta Histochem, In Press.
