Rene Vandenboom
Associate Professor
Kinesiology
Brock University
Canada
Biography
Although essential for terrestrial life, the role and importance of skeletal muscle function is often overlooked. My research interests are the structure-function relationships of skeletal muscle cells and the mechanics of skeletal muscle contraction. I am particularly interested in the mechanism of posttetanic potentiation and how this outcome enhances skeletal muscle performance. This interest includes how the posttranslational modification of the myosin “motor” molecule, by phosphorylation of the regulatory light chain, enhances contractile performance. I am also interested in the origin and implications of skeletal muscle fatigue.
Research Interest
Ontario College of Kinesiology; Ontario University Ball Hockey Association; Ontario Ball Hockey Federation; Canadian Ball Hockey Association
Publications
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Smith I, Gittings W, Bloemberg D, Huang J, Quadrialtero J, Tupling AR and Vandenboom R. Potentiation in Mouse Lumbrical Muscle Without Myosin Light Chain Phosphorylation: Is Resting Calcium Responsible? Journal of General Physiology 141(3): 297-308, 2013.
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Vandenboom R, Gittings W, Smith IC, Grange RW and JT Stull. Myosin Phosphorylation and Force Potentiation in Skeletal Muscle: Evidence from Animal Models. Journal of Muscle Research and Cell Motility 34(5-6): 317-332, 2013.
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Smith IC, Vandenboom R and Tupling R. Juxtaposition of the Changes in Intracellular Calcium and Force During Staircase Potentiation at 30 and 37oC. Journal of General Physiology 144(6):561-570, 2014.
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Gittings W, Aggarwal H, Stull JT and Vandenboom R. The Force Dependence of Isometric and Concentric Potentiation in Mouse Muscles With and Without Myosin Light Chain Kinase. Canadian Journal of Physiology and Pharmacology 93(1):23-32, 2015.
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Gittings W, Stull JT and Vandenboom R. Interactions Betweent the The Catch Like Property and Posttetanic Potentiation of Mouse Skeletal Muscle. Muscle and Nerve 54(2): 308-316, 2016.
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Bowslaugh JJ, Gittings W and Vandenboom R. Myosin Phosphorylation is Required for Peak Power of Mouse Fast Muscle In Vitro. Pflugers Archive: European Journal of Physiology 468(11): 2007-2016, 2016.
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Vandenboom R. Force Modulation in Skeletal Muscle by Myosin Phosphorylation. In: Pollack D (Ed) American Physiological Society. Comprehensive Physiology 7:171â€212, 2017.
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Gittings W, Bunda, JB and Vandenboom R. Shortening Speed Dependent Force Potentiation is Attenuated but not Eliminated in Skeletal Muscles Without Myosin Phosphorylation. Journal of Muscle Research and Cell Motility (In Press) 2017.
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Mikhaeil JS, Sacco SM, Saint C, Gittings W, Bunda J, Giles CR, Fajardo V, Vandenboom R, Ward WE and LeBlanc PJ. Influence of longitudinal micro-CT radiation on contractility and metabolic activity in mouse skeletal muscle. Submitted to Physiological Reports (Under Review) (2017)
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Smith IC, Vandenboom R and Tupling AR. Contraction-Induced Enhancement of Relaxation During Repeated High Force Contractions. Submitted to the Journal of Experimental Biology (Under Review) (2017).
