Robert Carlone
Professor
Faculty of Mathematics & Science
Brock University
Canada
Biography
Dr. Robert Carlone is affiliated to Faculty of Mathematics & Science, Brock University, where Dr. Robert Carlone is currently working as Professor. Dr. Robert Carlone has authored and co-authored several national and international publications and also working as a reviewer for reputed professional journals. Dr. Robert Carlone is having an active association with different societies and academies around the world. Dr. Robert Carlone made his mark in the scientific community with the contributions and widely recognition from honourable subject experts around the world. Dr. Robert Carlone has received several awards for the contributions to the scientific community. Dr. Robert Carlone major research interest involves We study the role of retinoids such as all-trans (atRA) and 9-cis retinoic acids in neuronal growth, development and regeneration in both vertebrate and invertebrate model systems. We use the spinal cord of the adult newt (Notophthalmus viridescens) to examine the role of atRA in a system capable of epimorphic regeneration into adulthood..
Research Interest
We study the role of retinoids such as all-trans (atRA) and 9-cis retinoic acids in neuronal growth, development and regeneration in both vertebrate and invertebrate model systems. We use the spinal cord of the adult newt (Notophthalmus viridescens) to examine the role of atRA in a system capable of epimorphic regeneration into adulthood.
Publications
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Carter C, Clark A, Spencer GE, Carlone RL. (2011). Cloning and expression of a retinoic acid receptor β2 subtype from the adult newt: Evidence for an early role in tail and caudal spinal cord regeneration. Developmental Dynamics. 240: 2613-2625.
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Szuroczki D, Vesprini ND, Jones TRB, Spencer GE, Carlone RL. (2011). Presence of Ribeiroia ondatrae in the developing anuran limb disrupts retinoic acid levels. Parasitology Research. 110: 49-59.
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Tattersall GJ, Tyson TM, Lenchyshyn, JR, Carlone RL. (2012). Temperature preference during forelimb regeneration in the red-spotted newt, Notophthalmus viridescens. Journal of Experimental Zoology. 317:248-258.
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Lepp, A and Carlone, R. (2014). RARβ2 expression is induced by the down-regulation of micro RNA 133a during caudal spinal cord regeneration in the adult newt. Developmental Dynamics. 243(12): 1581-1590.
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Carter, CJ, Rand, C, Mohammad, I, Lepp, A, Vesprini, N, Wiebe, O, Carlone, R and Spencer, G. (2015). Expression of a retinoic acid receptor(RAR)-like protein in the embryonic and adult nervous system of a protostome species. Journal of Experimental Zoology (Mol. Dev. Evol.). 324B: 51-67.
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Lepp, A C and Carlone, R L. (2015). MicroRNA dysregulation in response to RARβ2 inhibition reveals a negative feedback loop between microRNAs 1, 133a and RARβ2 during tail and spinal cord regeneration in the adult newt. Developmental Dynamics. 244: 1519-1537
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Lepp, A C, Haj-Ahmad, L, Rozema, D, Wlodarek, L, Kubarakos, E, Carlone , R. (2017). Inhibition of retinoic acid signaling with DEAB inhibits tail regeneration and alters miR-21 expression and targeting of jagged in the ependymoglial cells of the newt caudal spinal cord. Submitted Developmental Dynamics
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Rand, C, Spencer G, Carlone, R. (2017). Retinoic acid as a chemoattractant for embryonic spinal cord neurons of the African clawed frog, Xenopus laevis. Submitted Canadian J. of Zoology.
