Vincenzo De Luca
Professor
Biological Sciences
Brock University
Canada
Biography
Dr. Vincenzo De Luca is affiliated to Biological Sciences, Brock University, where Dr. Vincenzo De Luca is currently working as Professor. Dr. Vincenzo De Luca has authored and co-authored several national and international publications and also working as a reviewer for reputed professional journals. Dr. Vincenzo De Luca is having an active association with different societies and academies around the world. Dr. Vincenzo De Luca made his mark in the scientific community with the contributions and widely recognition from honourable subject experts around the world. Dr. Vincenzo De Luca has received several awards for the contributions to the scientific community. Dr. Vincenzo De Luca major research interest involves The major focus of my research has been in the elucidation of natural product biosynthesis in plants. This interest has oriented studies to the specialized organization, required to accommodate particular biosynthetic pathways. Model systems in my laboratory (Madagascar periwinkle (Catharanthus roseus) (Fig. 1) and in others have been used to study the cell and developmental biology required to create these specialized cells (Fig. 2 & 3). Studies have clearly established that natural products are produced within a small proportion of cells that compose the total organism. Cellular specialization appears to activate a) the supply of precursors derived from primary metabolic processes; b) specific biosynthetic pathways for converting primary metabolites into particular small molecules; c) particular sequestering mechanisms, including transport processes that trigger and permit the high level accumulation of end-products. In a few limited examples, large-scale sequencing of cDNA libraries prepared from individual cell-types has confirmed that plant cells become natural product biosynthesis factories through targeted biochemical differentiation..
Research Interest
The major focus of my research has been in the elucidation of natural product biosynthesis in plants. This interest has oriented studies to the specialized organization, required to accommodate particular biosynthetic pathways. Model systems in my laboratory (Madagascar periwinkle (Catharanthus roseus) (Fig. 1) and in others have been used to study the cell and developmental biology required to create these specialized cells (Fig. 2 & 3). Studies have clearly established that natural products are produced within a small proportion of cells that compose the total organism. Cellular specialization appears to activate a) the supply of precursors derived from primary metabolic processes; b) specific biosynthetic pathways for converting primary metabolites into particular small molecules; c) particular sequestering mechanisms, including transport processes that trigger and permit the high level accumulation of end-products. In a few limited examples, large-scale sequencing of cDNA libraries prepared from individual cell-types has confirmed that plant cells become natural product biosynthesis factories through targeted biochemical differentiation.
Publications
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G. Guillet, J. Poupart, J. Basurco, and V. De Luca (2000) Expression of Tryptophan Decarboxylase and Tyrosine Decarboxylase Genes in Tobacco Results in Altered Biochemical and Physiological Phenotypes Plant Physiol. 122: 933-944.
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F. Vazquez Flota, B. St. Pierre and V. De Luca (2000) Light activation of vindoline biosynthesis does not require cytomorphogenesis in Catharanthus roseus seedlings. Phytochemistry 55: 531-536.
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P. Laflamme, B. St. Pierre and V. De Luca (2000) Molecular and biochemical analysis of a Catharanthus roseus G. Don root-specific minovincinine 19-hydroxy-O-acetyltransferase. Plant Physiology 125: 189-198.
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B. St. Pierre and V. De Luca (2000) Evolution of acyltransferase genes: origin and diversification of the BAHD superfamily of acyltransferases involved in secondary metabolism. Rec. Adv. Phytochem. 34: 285-315.
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V. De Luca and B. St. Pierre (2000) The cell and developmental biology of alkaloid biosynthesis. Trends in Plant Sci. 5: 349-364.
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V. De Luca and P. Laflamme (2001) The expanding universe of alkaloid biosynthesis. Curr. Opinion in Plant Biology 4: 225-233.