Plante Isabelle

Biography

Professor-Researcher, Environmental Toxicology INRS-Institut Armand-Frappier Start: Summer 2011 Post-Doctoral Intern 2006-2011 University of Western Ontario Supervisor: Dale W. Laird Ph.D. 2006 Biology INRS-Institut Armand-Frappier Supervisor: Michel Charbonneau Co-supervisor: Daniel G. Cyr M.Sc. 2002 Experimental Sciences of Health INRS-Institut Armand-Frappier Supervisor: Michel Charbonneau Co-supervisor: Daniel G. Cyr B.Sc. 1999 Biology Laval University

Research Interest

Our research interests are aimed at determining the role of cellular interactions in the development of the mammary glands and in breast cancer. We are particularly interested in understanding the regulation and influence of gap junctions ("Gap Junctions"), tight and adherent in the development of the mammary glands, and how their deregulation by mutations or environmental pollutants can promote cancer of the mammary glands. breast. Identify the role of cellular junctions in the development of the mammary glands. The mammary gland is composed of two tissues: the stroma, mostly composed of adipocytes and fibroblasts, and the epithelium, formed by a layer of luminal cells surrounded by a layer of myoepithelial cells. Thus, the mammary gland is an ideal organ for studying cellular interactions since its development during puberty, the differentiation of epithelial cells during pregnancy and its functioning during lactation all seem to require a close interaction between the stroma and the lactation. epithelium, as well as between the luminal and myoepithelial cells of the epithelium, suggesting a primordial role of cell junctions in these processes.