Stéphane Lefrancois
Neurodegenerative diseases
Institut national de la recherche scientifique
Canada
Biography
Professor Stéphane Lefrancois is a graduate of McGill University where he obtained the BSc and PhD degrees (Anatomy and Cell Biology). He then pursued postdoctoral studies at the National Institutes of Health (USA) before becoming an Assistant Professor in the Department of Medicine at the University of Montreal. He is an Associate Professor in the Department of Anatomy and Cell Biology at McGill University.
Research Interest
The aim of my research program is to elucidate the mechanisms used by cells to regulate intracellular sorting and trafficking with emphasis on transport to and from the lysosomal compartment and the basolateral compartment of the polarized cells. Sorting and efficient trafficking to the lysosome are essential cellular functions that have important consequences on human health. Although rare individually, the combined incidence of more than 50 lysosomal diseases is 1: 5000 births worldwide. Interestingly, several proteins necessary for lysosomal screening and trafficking have been implicated in various other diseases, including muscular dystrophy, diabetes and Alzheimer's disease.
Publications
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Analysis of AQP4 trafficking vesicle dynamics using a high content approach Mazzaferri J, Costantino S and Lefrancois S (2013) Biophys. J. 105:328-337
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Adaptive settings for single particle tracking algorithms Mazzaferri J, Roy J, Lefrancois S and Costantino S (2015) Bioinformatics. 31:1279-85
