Michael P. Walsh

Biography

Michael P. Walsh is a Professor in Department of Biochemistry & Molecular Biology , Faculty of Medicine in University of Calgary  and scientist in Alberta Heritage Foundation for Medical Research and  Chair (Tier I) in Vascular Smooth Muscle Canadian Research  and  Elected Fellow of the Royal Society of Canada           

Research Interest

Research in the Walsh laboratory is focused on signal transduction pathways involved in the regulation of smooth muscle contraction and relaxation. Areas of interest include: Mechanisms of calcium sensitization of vascular smooth muscle contraction Mechanism of regulation of urethral smooth muscle contraction by Rho-associated kinase Calcium-independent phosphorylation of smooth muscle myosin The mechanism of activation of myosin light chain kinase by calcium and calmodulin The roles of protein kinase C and Rho-associated kinase in phosphorylation and inhibition of myosin light chain phosphatase and the phosphatase inhibitor CPI-17 The molecular basis of myogenic tone regulation in the vasculature (in collaboration with Dr. Bill Cole) Development of highly sensitive proteomic methods for the analysis of myosin phosphorylation in the renal microvasculature (in collaboration with Dr. Rodger Loutzenhiser)