A. Gregorieff
Assistant Professor
DEPARTMENT OF PATHOLOGY
McGill University
Canada
Biography
My current research interests stem from my doctoral thesis in the lab of Dr. Hans Clevers in the Netherlands. During this time, I studied the Wnt/Tcf pathway and its role in driving intestinal development and homeostasis. Next, I moved to Toronto to pursue my postdoctoral training in the lab of Dr. Jeff Wrana at the Lunenfeld-Tanenbaum Research Institute. Here, I became interested in studying the role of the Hippo signaling effector, Yap, in intestinal stem cells during regeneration and cancer initiation. In 2017, I was appointed assistant professor in the department of pathology at McGill University. My future research goals will be to study the role of the Hippo pathway in stromal cells during gut homeostasis and tumorigenesis. Secondly, I am also interested in dissecting the signals underlying cellular plasticity of adult stem cells. To achieve these goals, I am currently developing a broad range of genetic tools including Cre-lox based mice for gene targeting and lineage tracing experiments, as well as ex vivo organoid culture systems.
Research Interest
pathology
Publications
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YAP and TAZ control peripheral myelination and the expression of laminin receptors in Schwann cells Poitelon Y, Lopez-Anido C, Catignas K, Berti C, Palmisano M, Williamson C, Ameroso D, Abiko K, Hwang Y, Gregorieff A, et al. Nat Neurosci 2016, 19:879-887
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A critical role for NF2 and the Hippo pathway in branching morphogenesis Reginensi A, Enderle L, Gregorieff A, Johnson RL, Wrana JL, McNeill H Nat Commun 2016, 7:12309.
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Hippo signalling in intestinal regeneration and cancer Gregorieff A, Wrana JL Curr Opin Cell Biol 2017, 48:17-25.
