Aimée K. Ryan
Associate Professor
Departments of Pediatrics and Human Genetics
McGill University
Canada
Biography
Postdoctoral Training: University of California San Diego PhD: Biochemistry, Queen's University MSc: Biology (Human Genetics), Queen's University BSc: Honours Genetics, University of Manitoba
Research Interest
My laboratory is investigating the molecular mechanisms that direct morphogenesis during early embryonic development. Morphogenesis literally means “creation of shape”. It is the process that drives the formation of organs and tissues and is required to generate the structurally complex 3-dimensional embryo. The forces that drive morphogenesis begin at the level of the cell and include changes in cell shape and adhesion, as well as changes in rates of proliferation and orientation of cell divisions. At the tissue level, groups of cells must undergo directed and coordinated movements that depend on the ability of cells to communicate with their neighbours. Throughout these movements, cells must remain oriented with respect to the anterior-posterior, dorsal-ventral and left-right axes of the embryo.
Publications
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Coate TM, Raft S, Zhao X, Ryan AK, Crenshaw EB 3rd, Kelley MW. (2012) Otic mesenchyme cells regulate spiral ganglion axon fasciculation through a Pou3f4/EphA4 signaling pathway. Neuron. 73(1):49-63.
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Collins, M.M., Baumholtz, A.I. and Ryan, AK (2012) Claudin-5 expression in the vasculature of the developing chick embryo. Gene Expression Patterns (in press; ePub available online 2 Feb 2012)
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Collins, M.M., Baumholtz, A.I. and Ryan, A.K. (2013) Claudin family members exhibit unique temporal and spatial expression boundaries in the chick embryo. Tissue Barriers. 1(3): e24517
