Alba Guarné
Professor
Biochemistry
McGill University
Canada
Biography
1999 - PhD, University of Barcelona
Research Interest
Our goal is to understand how proteins determine the fate of DNA during chromosome replication and repair. In particular, how regulatory proteins orchestrate the stabilization of damaged replication forks with DNA repair and forks restart. Since most of the proteins that regulate these processes lack a measurable enzymatic activity, our efforts are aimed at seeing how they work using a broad range of structural biology techniques. We then combine structural information with biochemical and genetic analysis to elucidate their functions at a molecular level.
Publications
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Large-scale production of recombinant Saw1 in Escherichia coli. Rashev M, Surtees JA, Guarné A.
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The cryo-EM structure of YjeQ bound to the 30S subunit suggests a fidelity checkpoint function for this protein in ribosome assembly. Razi A, Guarné A, Ortega J.
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Complementary uses of small angle X-ray scattering and X-ray crystallography. Pillon MC, Guarné A.
