Andrey Cybulsky
Associate Member
Psychiatry
McGill University
Canada
Biography
Division of Nephrology
Research Interest
1) Mechanisms of immune glomerular cell injury and proteinuria. Role of phospholipases, protein kinases, and stress proteins. 2) Role of SLK (a Ste-20-like kinase) in renal ischemia-reperfusion injury. Mechanisms/regulation of kinase activation, signaling effectors, functional effects, including apoptotic pathways. 3) Regulation of protein kinase signaling by extracellular matrix in the glomerulus. Activation of protein kinases, mediators of apoptosis/cell survival.
Publications
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Deletion of inositol-requiring enzyme-1α in podocytes disrupts glomerular capillary integrity and autophagy. Kaufman DR, Papillon J, Larose L, Iwawaki T, Cybulsky AV.
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Regulation of Ste20-like kinase, SLK, activity: Dimerization and activation segment phosphorylation. Cybulsky AV, Guillemette J, Papillon J, Abouelazm NT.
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Endoplasmic reticulum stress, the unfolded protein response and autophagy in kidney diseases. Cybulsky AV.
